Recovery post radiation squamous cell carcinoma tongue. This commentary will focus on carcinoma of the tongue. These tumors usually arise from the ventrolateral aspect of the mid and. Histological analysis revealed a low grade squamous cell carcinoma scc of the tongue. These cells form on the surface of the skin, on the lining of hollow organs in the body, and on the lining. Squamous cell carcinoma tongue is the commonest dorsum table3 results majority of patients 75% were male with a male to female ratio of 3. Importance positive margins are associated with poor prognosis among patients with oral tongue squamous cell carcinoma scc. C3 vertebral metastases from tongue adenoid cystic carcinoma. The various treatment options for the tongue carcinoma include surgery, radiotherapy, chemotherapy and combined modalities. Distant metastases of a squamous cell carcinoma of the.
In western countries, oral cavity squamous cell carcinoma represents approximately 3% of new cancer diagnoses annually 3. The diagnosis often represents a clinicalpathological. Nccn clinical practice guidelines in oncology nccn. Several types of cancer grow in the tongue, but squamous cell carcinoma is the most common. Mr findings suspicious for a right lateral oral tongue carcinoma, maximum depth 6. The case was confirmed as a squamous cell carcinoma of the tongue. Objective to determine the effect of the margin sampling technique on local recurrence lr in patients with stage i or ii oral tongue scc design, setting, and participants a retrospective study was. It may be difficult to eat, swallow food, or even to speak. Excision margins in squamous cell carcinoma of the tongue.
Multiinstitutional trial of accelerated hypofractionated intensitymodulated radiation therapy for earlystage oropharyngeal cancer rtog 0022. Tongue carcinoma in an adult downs syndrome patient. Recurrence at this site is also more difficult to identify at an early stage during post treatment surveil lance and more difficult to treat with further surgery, especially if the tongue has been reconstructed with free tissue transfer. The treatment of choice is a surgical excision glossectomy with clear margins followed by radiation therapy or chemotherapy, as decided by the healthcare. Tongue cancer is a type of cancer that starts in the cells of the tongue, and can cause lesions or tumors on your tongue. Squamous cell carcinomas sccs, also known as epidermoid carcinomas, comprise a number of different types of cancer that result from squamous cells. Get a printable copy pdf file of the complete article 759k. What are the clinical features of carcinoma in situ of the oral cavity. Squamous cell carcinoma of tongue in a 19yearold female randhawa t, shameena pm, sudha s, nair rg department of oral pathology and microbiology, government dental college, calicut 673 008, kerala, india. Squamous cell carcinoma of the base of tongue springerlink. Extends from skin vermilion junction of lips to junction of hard and soft palate above. Squamous cell carcinoma scc is the most prevalent malignant neoplasm of the oral cavity. Squamous cell carcinoma of the tongue has tobacco smoking and alcohol ingestion as major risk factors and spans two regions.
Case squamous cell carcinoma of tongue in a 19yearold. In general, squamous cell carcinoma of tongue is an aggressive form of cancer. Below it is limited to circumvallate papilla of tongue. Fortunately, if detected early, these malignancies may have a more favorable prognosis. To our knowledge, the mr imaging appearance of this entity has not been described. Early carcinoma in situ of the oral cavity is a slightly elevated greywhite plaque either well defined or which blends in gradually with surrounding mucosa.
For example, basaloid scc is an aggressive tumour and verrucous carcinoma has the lowest invasive. The over all risk is similar to that in adult population. Mouth cancer is a major neoplasm worldwide and theoretically should be largely preventable or detectable at an early stage. Tongue cancer is the most common type of oral cancer 1.
Carcinoma of the tongue is a type of skin cancer that appears on some part of the tongue. Or it may occur at the base of the tongue, near where it attaches to the bottom of your mouth. Primary tumour of the kidney metastasizing to the tongue is very unusual and only anecdotal cases have been reported. I was diagnosed with squamous cell carcinoma of the tongue on apr 19, 2012, after excision biopsy conducted on apr 14.
The lesions may ulcerate and cause scarring of the tongue. A 66yearold female patient was admitted to our department with a large tumor of the tongue measuring 10 cm in diameter. Tongue squamous cell carcinoma, 18ffdg, positronemission tomography and computed tomography, stage introduction. Bilateral enlarged cervical lymphatic masses were also present. If metastasis such as to the local lymph nodes is observed, then the prognosis is guarded or unpredictable tumors in their early stage with complete excisional treatment typically have good prognosis. European statistics indicate an incidence of around 1020 per 100 000 of. Squamous cell carcinoma of the base of tongue is known to have a poor clinical prognosis that is primarily attributable to such tumors usually presenting at an advanced stage. The average age of presentation was 55 years with age range of 28 81 years. Carcinoma was identified as stage 1, t2, confined to left margin of the tongue. The symptoms of tongue cancer include a painful tongue, redness, and sores or ulcers that will not heal. One of the first signs of tongue cancer is a lump or sore on the side of your tongue that doesnt go away. Pdf spindle cell squamous carcinoma of the tongue in a child. Out of those, only 3 cases presented initially with tongue metastases before the diagnosis of primary renal cell carcinoma.
Introduction squamous cell carcinoma scc of the tongue is the most frequent intra oral head and neck cancer. The prognosis for patients with lingual metastasis of. Andrew of glasgow presents some very surprising statistics relative to epithelioma of the tongue. Homogeneous refers to homogeneous uniform colour and texture. Clear cell carcinoma ccc also known as clear cell adenocarcinoma and hyalinizing clear cell carcinomahccc is one of the rarest tumors of the minor salivary glands and infrequently occurs at the base of the tongue. Our patient data show that microrna424 alterations are a marker of field cancerisation specific for tongue tumourigenesis, which also could have a role in development of tongue squamous cell. Recurrent squamouscell carcinoma tongue with lung metastases dr. Without early treatment, the cancer may spread to other parts of the body, creating a potential medical crisis. Epidermoid carcinoma of the mobile tongue pdf free download. In sri lanka, india, pakistan and bangladesh, nearly a quarter of total cancer diagnoses are oral cavity squamous cell carcinoma. Malignancies of the tongue represent one of the greatest management challenges for the head and neck oncologist because of the adverse effects of treatment on oral and pharyngeal function, the eventual quality of life, and the poor prognosis of advanced disease. It is the eighthleading cause of cancerrelated deaths in the united states leading to approximately 8000 deaths per year.
Due to the mutilating affects of the surgical management of tongue carcinoma on the quality of life, organ preservation techniques and. Approximately 90% of oral cancers are squamous cell carcinoma scc, which is seen typically on the lip or lateral part of the tongue usually as a lump or ulcer that is white, red, or mixed white and red. It can be a localised solitary lesion or multifocal and diffuse two clinical forms are recognised. The squamous cell carcinoma may appear as slowgrowing skin lesions. December the american journal 1971 of surgery volume 122 number 6 epidermoid carcinoma of the mobile tongue treatment by partial glossectomy alone ronald h. Squamous cells are thin, flat cells that line the mouth and other organs. Squamous cell carcinoma tongue radiology reference. However, wide variation exists in the margin sampling technique. If the cancer is on the forward portion of the tongue, it is known as a squamous cell cancer of the oral tongue. The tumor occupied nearly the entire oral cavity and showed exophytic and ulcerative areas.
The national comprehensive cancer network nccn makes no representations or warranties of any kind regarding their content, use or application and disclaims any responsibility for their application or use in any way. Patient was operated for segmental glossectomy, modified radical neck dissection of left. The patient underwent a hemiglossectomy without neck dissection followed by a postoperative. Of 118 cases comprising various diseases of this organ, such as abscess, hematoma, glossitis, leucoplakia, papilloma, and tuberculous ulcer, 98 were. Aniceto g, spindle cell squamous carcinoma of the tongue in a child, oral and maxillofacial surgery cases 2016, doi. It is considered to be a biphasic tumor made up of cells from squamous and spindle cells carcinoma with a sarcomatous aspect, but of epithelial origin. The front twothirds of the tongue that you can stick out is called the oral tongue. Activation of p53 signalling in acetylsalicylic acidinduced apoptosis in oc2 human oral cancer cells. Tongue carcinoma free download as powerpoint presentation.
Tongue carcinoma has become a devastating cause of morbidity in this era of tobacco consumers. Anatomy of oral cavity extends from skin vermilion junction of lips to junction of hard and soft palate above below it is limited to circumvallate papilla of tongue. Treatment selection for carcinoma of the base of tongue. In a series of 76 patients with carcinoma of the tongue the occurrence of metastasis was related to the size and histological features of the primary tumour.
Tongue cancer can occur on the front of the tongue, which is called oral tongue cancer. Note the normal contralateral mylohyoid muscle short arrow. Tongue metastasis as an initial presentation of renal cell. Original article ffdg pet ct in diagnosis and staging of. Squamous cell carcinoma of left lateral border of tongue. This tumor has tobacco smoking and alcohol ingestion as major risk factors. The exact cause is unknown, but risk factors include smoking and heavy alcohol consumption. Because of their location, routine detection is possible early in their presentat. Symptoms of carcinoma of the tongue may include abnormally colored patches of skin on the tongue, a lump or sore that will not go away, or difficulty swallowing. Nimotuzumab in treatment of infiltrating squamous cell. Sometimes the sore will bleed if you touch or bite it. Imaging of tongue carcinoma 189 a b c figure 4 a axial postcontrast t1 weighted fatsuppression image shows a rightsided oral tongue carcinoma arrow. If the cancer is located towards the rear third of the tongue, it is known as a squamous cell cancer at the base of the tongue. Squamous cell carcinoma is the most common type of tongue cancer.
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